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Bone Marrow Transplant Cost in India

Last Modified: February 22, 2022  |   Created on: July 3, 2018
Blood Cancer, Blood Disorder, Transplants

“Bone marrow transplant cost in India starts from USD 15,000 (₹ 10,86,000) for autologous bone marrow transplant and USD 22,000 (₹ 15,60,000) for allogeneic bone marrow transplant. The bone marrow transplant hospitals in India promise unparalleled health treatments at low-cost packages.

Bone Marrow Transplant Cost in India

The following table indicates details about Bone Marrow Transplant Cost in India:

 

Type of TransplantAutologous BMTAllogenic BMT
  Full Match (HLA testing >80%)Half Match (HLA testing <80%)
Cost15,000 USD22,000 USD40,000 USD
DonorNot RequiredRequired
ChemotherapyRequiredRequired
Stay in Hospital25 – 35 Days1 Month
Stay in Country2 Months2 Months
Accommodation CostStarting 20 USD/DayStarting 20 USD/Day

Testimonial:11 year old boy from Zambia treated in India for a Bone Marrow Transplant (BMT)

The Bone marrow transplant procedure was a complete success. The child is now on his path to immune recovery. It was not at all easy…but it was very much worth it!! We’re deeply touched by the passion of Dr. Surbhi and her team Lyfboat.

Pre-transplant tests for BMT in India

Type of diagnostic Test

List of tests

Type of transplant

Patient

Donor

Blood tests

  • HLA-Crossmatch and Typing
  • Infectious disease screening for HIV, Hepatitis, etc. 
  • Organ function tests, including CBC, ABO blood typing, etc.

Allogeneic BMT

Autologous/Allogeneic BMT

Autologous/Allogeneic BMT

Yes

Yes

Yes

Yes

Yes

Yes

Heart function tests 

  • Electrocardiogram
  • Echocardiogram

Autologous/Allogeneic BMT

Yes

Yes

Pulmonary function tests

  • Spirometry test
  • Lung volume tests
  • Lung diffusion capacity
  • Pulse oximetry

Autologous/Allogeneic BMT

Yes

Yes

Other tests

  • PET Scan
  • CT Scan

Autologous/Allogeneic BMT

Yes

Yes

Bone marrow tests

  • Bone marrow biopsy

Autologous/Allogeneic BMT

Yes

Yes

What are the factors that affect Bone Marrow Transplant Cost in India?

Bone marrow transplant cost in India starts at as low as $15,000 for treatment of conditions like Myeloma, but this price varies for other medical conditions. The overall Bone marrow transplant cost in India also depends on the following factors:

  • Availability of Donor
  • The severity of the patient’s condition
  • Type of transplant required
  • Location, type, and clinical infrastructure of the hospital
  • Duration of hospital stay
  • The expertise and fee of the surgeon
  • Diagnostic and other laboratory tests

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What is a Bone marrow transplant?

Bone marrow is a soft tissue present inside the bones consisting of stem cells that produce WBCs, RBCs, and platelets. Under certain conditions like cancer, these stem cells lose their ability to produce normal and healthy blood cells.

A bone marrow transplant replaces the diseased or non-functional bone marrow with healthy stem cells. These stem cells can be derived from the patient’s body or a full-match or half-match donor. In a few cases, these stem cells can also come from the cord blood cells preserved at the time of the patient’s birth.

Types of Bone Marrow Transplants in India

Inforgraphics-Autologous-BTM

Autologous Transplant:

Autologous bone marrow transplants the healthy stem cells derived from the patient back into their body. The stem cells are collected through apheresis, purified, and stored for future use. Meanwhile, the patient begins with their chemo or radiation therapy treatment. These therapies destroy the non-functional and sometimes a part of the functional bone marrow as well. Once the therapy is completed, the stem cells are transplanted back into the patient’s body through an intravenous catheter.

Allogenic Transplant:

This type of bone marrow transplant involves extracting the donor’s bone marrow, also called peripheral stem cells. This bone marrow is matched genetically and may or may not relate to you. Doctors may follow syngeneic bone marrow transplant that includes receiving peripheral stem cells and bone marrow of identical twins.

Bone marrow transplant Donor in India

An individual is eligible to become a BMT donor if they are histocompatible with the patient. This means that their genetic makeup closely resembles that of the patient. Generally, a matching donor is from the immediate family, a child, a sister or brother, or a parent.

However, a patient can also get the best match through an unrelated donor. A cent-percent match is not necessary, but a close match for a positive outcome is indispensable.

The ideal BMT donor should:

  • Be between 18 and 44 years of age
  • Not have a BMI more than 35 and less than 18
  • Not suffer from any mental illness
  • Not suffer from any neurological disease
  • Not suffer from chronic heart or lung conditions
  • Not suffer from diabetes
  • Not suffer from any blood disorder
  • Not suffer from infections such as HIV, Hepatitis C, Syphilis, etc.
  • Not be pregnant 

Becoming a BMT Donor in India

  • If an individual decides to donate their bone marrow or stem cells (Both for a related or unrelated patient/recipient), they will have to undergo a comprehensive evaluation with a doctor to check their eligibility.
  • The donor will be informed about the risks and complications associated with the procedure and inquired about their medical history. This will include a series of tests to screen possible genetic or infectious diseases. 
  • If the doctor deems the donor to be eligible for donation, they will undergo an HLA typing test to check the histocompatibility with the patient. 
  • There are two ways through which stem cells can be extracted from the donor’s body. These include:

Type of Donation

Bone Marrow Donation

Peripheral Blood Stem Cell Donation

What does it involve?

The donor will undergo a surgery that will require an overnight hospital stay. The surgeon will insert a needle in the posterior region of the pelvic bone and aspirate a portion of the marrow. The surgery will be performed under anesthesia.

This type of donation is done as an outpatient procedure. The donor will be administered injections starting a few days before the procedure to promote stem cell number in the blood. On the day of the procedure, a catheter will draw blood out of the patient’s vein (usually arm), circulate it in a machine, and send it back into the patient’s body. The machine filters out stem cells from the blood and this process is called as apheresis.

Time taken for the donation

1 to 2 Hours

2 Hours (May require more sittings, depending on the number of stem cells required by the patient.) 

Recovery 

3 to 4 Weeks

7 to 14 Days

Risks or Complications

Soreness in the treated area and difficulty in walking for a few days.

Bone pain, Muscle ache, nausea, vomiting, weakness, fatigue, and infection (in rare instances).

 

Finding a BMT Donor in India

Finding a BMT donor in India can be quite challenging. The  National Organ and Tissue Transplant Organization (NOTTO) doesn’t include a registry for this specific category. There are a few independent organizations like MDRI and Daitri that provide these services and information.

Patients can register their details and find the best possible match. On the other hand, if anyone wishes to list themselves as a donor, they too can register and share necessary details for future reference.

What does a BMT procedure in India involve?

Before the procedure

  • The procedure to undergo BMT in India begins with a thorough physical evaluation, including routine blood tests and functional analysis of the heart, lungs, and liver. These tests help the doctor to decide the patient’s eligibility for the procedure.
  • If the patient is fit for a bone marrow transplant, the doctor will discuss the possible options they have. This will also include finding a suitable donor if the patient can’t undergo an autologous transplant. 
  • A few days before the surgery, the patient will be required to visit the hospital to get an intravenous catheter implanted into a vein in the neck or the chest. This catheter will stay put during the treatment to infuse transplanted stem cells and medication into the patient’s body. 

During the procedure

1. Collection of stem cells

The process of BMT begins with the first and most essential step – The collection of stem cells. Stem cells can come from two sources; the patient’s own body or stem cells obtained from a suitable donor. The collection of stem cells takes place in the following ways. 
  • Autologous transplant
  • The patient will receive a daily dose of injections that will stimulate stem cell production at a faster and higher rate. These injections contain growth factors that supplement stem cell formation and differentiation. 
  • After a few days, the patient will visit the hospital for a process known as ‘apheresis.’ 
  • Apheresis is a technique to draw blood from the patient’s body, circulate it in a specialized machine, separate stem cells from the blood, and finally, direct the blood back to the patient. 
  • The collected stem cells are purified and frozen for further use. 
  • Allogeneic transplant
  • The stem cells from an allogeneic source can be collected in two different ways – through apheresis or surgery. 
  • The doctor will suggest the option that works best for the donor as well as the patient. 
  • If the doctor advises apheresis, the donor will undergo a similar procedure listed above. But, if the doctor deems surgery to be a more suitable choice, the donor will have to undergo one. 

2. Conditioning

  • The next step requires a patient to go through a process called conditioning to prepare their body for transplant.
  • During conditioning, they will undergo chemotherapy and radiation therapy. A person may undergo chemotherapy, radiation, or have a combination of both these treatments during their conditioning. This plays a vital role in:
  1. Destroying cancer or diseased cells in the body as a treatment modality for the underlying condition.
  2. Suppressing the immune system (to allow it to accept the transplant cells)
  3. Preparing the bone marrow for the new stem cells
  • The type and amount of conditioning the patient receives depends on several factors, including the target disease, their overall health, and the type of bone marrow transplant. 

3. Reduced-intensity conditioning

  • The top bone marrow transplant hospitals in India offer this kind of conditioning for some patients. 
  • The reduced-intensity conditioning process involves the use of lower doses or different types of chemotherapy or radiation during the treatment. 
  • The doctor will recommend reduced-intensity conditioning based on the patient’s age and overall health status.
  • This conditioning will destroy some diseased cells and suppress the immune system to prevent chances of rejection. 

4. Bone marrow transplant

  • The transplant infusion itself is a painless process, and the recipient remains awake during the procedure. It takes a few hours to complete the procedure.
  • For the transplant, a central line is used to transfer the collected stem cells into the recipient’s body. 
  • Stem cells that were frozen have to be thawed before the transplant. They contain a preservative that may cause certain side effects in the patient. The doctor will administer certain medicines in such cases to help prevent any complications. Sometimes, extra fluids are also given to flush the preservatives out of the body.
  • A central venous catheter, or port, is installed on the upper portion of the patient’s chest. The fluid containing new stem cells flows directly into the heart through the catheter and gets dispersed throughout the body. 
  • As the stem cells reach the bone marrow, they become established and grow to increase their number. 
  • The blood cell count will return to normal within a few weeks. The patient will have regular blood count tests, meanwhile, to monitor the progress.

After the procedure

  • As the new stem cells are transplanted into the patient’s body, they will gradually reach the bone marrow via blood. With time, these stem cells differentiate and start producing different types of blood cells. This process is called engraftment and can take anywhere between 2 and 4 weeks.
  • During this period, the patient will remain susceptible to multiple risks and complications, including:
  1. Infections 
  2. Mucositis or Mouth sores
  3. Veno-Occlusive Disease of the Liver (VOD)
  4. Interstitial Pneumonia Syndrome (IPS)
  5. Graft-versus-Host Disease
  6. Graft Failure
  7. Cataracts
  8. Infertility
  9. New cancers

How can Lyfboat assist you getting Bone Marrow Transplantation in India?

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Graft-Vs-Host Disease (GVHD) in bone marrow transplant

  • This condition is a potential risk that may occur anytime after the transplant, especially in allogeneic bone marrow transplants.
  • GVHD occurs when the new donor stem cells that grow and rebuild the patient’s new immune system identify the body’s tissues and organs as foreign agents and start to attack them.
  • The risk of GVHD is more when the stem cells are obtained from an unrelated donor, but it may happen to anyone who receives stem cells from a donor. 

GVHD can be classified into two categories:

  • Acute GVHD: This usually occurs during the first few months after the transplant. It typically affects the skin, liver or digestive tract, and gut. This may cause symptoms, such as skin rashes, stomach pain, vomiting, diarrhea, or an increase in liver enzymes.
  • Chronic GVHD: This usually develops sometime later and may affect several organs. The signs and symptoms that indicate chronic GVHD include:
  1. Pain in the joint or muscle 
  2. Breathlessness
  3. A persistent cough
  4. Changes in the vision, such as dry eyes
  5. Scarring or stiffness on the skin 
  6. Yellow pigmentation on the skin or whites of eyes – jaundice 
  7. Dry mouth or Mouth sores
  8. Diarrhea
  9. Nausea and vomiting
  • As a solution to GVHD, the doctor will prescribe certain immunosuppressive and anti-inflammatory medications such as steroids to provide relief from the symptoms.
  • The choice and length of treatment depend on the type of condition – acute or chronic. Patients with GVHD may undergo treatment for almost a year or more, depending on their response to therapy.

Life after bone marrow transplant in India

A bone marrow transplant can help cure a variety of conditions or push them into remission. In both cases, the patient can expect improvement in the quality of life and high life expectancy rates. However, the results of a bone marrow transplant can be different for each patient. This usually depends on the type of disease and the age & general health of the patient.

Recovery

  • The patient will stay under close observation and care for at least one week in the hospital. The duration of hospital stay will depend on the severity of the patient’s condition and general health. 
  • Once the patient’s health is stabilized, the doctor will allow the patient to leave the hospital under the care of a medical attendant. The patient, in this case, should have a stable RBC and platelet count and should not be suffering from any fever. 
  • The doctor will advise the patient to find temporary accommodation near the hospital for a few weeks to months after the transplant. This helps them to have better control over the anticipated risks and complications associated with BMT. 
  • The patient will also need periodic RBC and platelet transfusions until the newly transplanted bone marrow starts producing sufficient levels of such cells on its own.
  • The recovery period will also require the patient to attend regular follow-ups with the doctor that can last for a few weeks, months, to even years. 

Aftercare

  • The aftercare routine aims to control the side effects of not only the transplant but also the chemo/radiation therapy. 
  • The most essential step in the aftercare of BMT is compliance with the post-procedure instructions as well as regular intake of prescribed medicines. These medications help to control the side effects of the treatments and reduce the chance of immune rejection. 
  • Apart from this, the patient will also be expected to make certain changes in their diet and overall lifestyle. These often include:
  1. Observe food safety procedures to prevent foodborne infections.
  2. Follow a healthy, balanced, and all-inclusive diet composed of fruits, vegetables, lean meats, poultry, legumes, whole grains, olive oil, etc.
  3. Limit the intake of dietary salt.
  4. Avoid smoking or alcohol.
  5. Avoid going to crowded places to minimize chances of infection
  6. Follow an active lifestyle that promotes weight control, strengthened bones, increased endurance, and healthy muscles. 
  7. Wear sunscreen whenever stepping outside.
  8. Get regular screenings for cancer.
Feel Free to ask your medical concern

Frequently asked Questions (FAQs) about Bone Marrow Transplant in India

Q. How much does Bone Marrow Transplant cost in India?

The average cost of a Bone Marrow Transplant in India is approximately Rs. 10,86,000 to 15,60,000 (USD 15,000 – USD 22,000). However, the prices may vary depending upon the hospitals in different cities.

Q. How much time does it take to recover after Bone Marrow Transplant?

Autologous bone marrow transplant recovery time is usually one month, while allogeneic bone marrow transplant recovery time is at least three months. Blood count usually starts to improve only after 10 to 20 days after the transplant. In the process, the patient is continuously monitored so as to keep infections at bay. When the blood count rises, the patient’s medical condition shows better signs of improvement.

Q. What are the complications of Bone Marrow Transplant?

Some of the complications of bone marrow transplant include bleeding, infection, liver disease and graft-versus-host disease. The pain from the complications arising out of the transplant is controlled by medication. In addition to these, mouth sores may develop making swallowing and chewing uncomfortable. Sometimes, temporary mental confusion is another major sign of complications after bone marrow transplant.

 Q. What is bone marrow and why is it required?

Bone marrow is a spongy tissue, which is present inside the breastbone or bones in the skull, ribs, spine and hips. This spongy tissue comprises of stem cells that help produce three types of blood cells in the human body. These include red blood cells, white blood cells, and platelets.

Red blood cells, also known as erythrocytes, help to carry oxygen in the blood and eliminate waste from it, while white blood cells, known as leukocytes, help to fight infection. Platelets, on the other hand, enable blood to clot.

Q. Why is Bone Marrow Transplant performed?

Bone marrow transplant helps provide a new lease of life to patients suffering from life-threatening conditions, including leukemia or multiple myeloma.

Q. How do they do a bone marrow transplant?

Bone marrow produces different types of blood cells including WBCs, RBCs, and platelets. If the stem cells fail to produce normal and healthy blood cells, then doctors recommend bone marrow transplant for replacing diseased bone marrow with a healthy one. This new stem cell is taken from a donor and implanted in the recipient’s body that further helps to produce healthy blood cells.

Sometimes for the treatment of certain cancers, the bone marrow is taken from the body of the patient itself before transplanting it back into their bodies. In the middle of the two procedures, the patient is made to undergo radiation treatment and chemotherapy, which end up destroying the healthy bone marrow. The bone marrows retrieved from the body of the patient before radiation and chemo is then transplanted.

Q. Can I undergo bone marrow transplant?

The best candidates for bone marrow transplant include individuals who are suffering from diseases certain forms of blood cancer such as myelodysplasia, leukemia, lymphoma and multiple myeloma, thalassemia, severe immunodeficiency syndrome, aplastic anemia, low blood cells counts, immature blood cells, excessive production of immature blood cells, sickle cell anemia and congenital neutropenia.

The cancer patients may require bone marrow transplant if their bone marrow gets damaged by radiation or chemotherapy. The only treatment for this medical condition is radiation or chemotherapy. The chemotherapy and radiation treatment procedure help to destroy abnormal blood cells and abnormal stem cells.

However, in the process, the normal cells are also destroyed. At the same time, aggressive chemotherapy can even damage healthy bone marrow. Only a bone marrow transplant can help save the patient by replacing the destroyed bone marrow.

Q. How do you donate bone marrow?

When a patient suffers from diseased or damaged bone marrow that is unable to produce good and healthy blood cells, he or she needs the stem cells derived from a donor for transplant. A person is eligible to become a BMT donor if his or her tissues closely match with that of the patient’s tissues.

Generally, a matching donor is from the immediate family, a child, a sister or brother or a parent. However, if a person is lucky then he or she can get the best match in a volunteer too. A cent percent match is not necessary, but the close match with a positive outcome is indispensable.

Another source of BMT cells is from the placenta and umbilical cord of a newborn. If these cells are collected from the baby and then frozen in a stem cell bank, they can be successfully used later for bone marrow transplant. This type of transplant is clinically termed cord blood transplant.

Q. Is it painful to be a bone marrow donor?

The notion that bone marrow donation is painful is a myth. A large majority of people who have donated some bit of their bone marrow confess themselves that it is a completely painless and comfortable procedure.

Bone marrows can be derived by two methods – either from the pelvic bone under the influence of general anaesthesia or from the blood stream of the patient. Prior to the second procedure, the donor is given hormone injections to make the stem cells multiply in the blood stream itself. Next, blood is taken from the donor to extract stem cells from them.

Q. Is it dangerous to donate bone marrow?

Bone marrow donation is a simple, outpatient, and painless procedure. The donor can go home on the same day of donation but may feel a bit tired for a few days. 

Otherwise, it is a completely safe and risk-less procedure. The only major risk that the donor suffers from is a reaction to anaesthesia, but it is a very rare complication. Donors aged between 18 and 44 are considered to be the best candidates for bone marrow donation because of minimal risk of complications.

Q. What to expect after bone marrow transplant?

Life can be both worrisome and exhilarating post bone marrow transplant. Patients have to visit doctors often to be closely monitored. However, a bone marrow transplant is, indeed, a blessing after being close to death. Life can drastically improve after the transplant.

Q. What are stem cells?

Stem cells have the potential to develop into some or many different types of cell in the body. It depends on whether they are pluripotent or multipotent. They Serves as a sort of repair system. They can theoretically divide without limit to replenish other cells for as long as the patient is alive.

Each daughter cell has the potential to either remain a stem cell or become another type of cell with a more specialized function in case od division of cells. Some of the examples of these cells are muscle cell, red blood cell, or brain cell.

Questions? Let us know.
Simran Bahia

Written By Simran Bahia

Simran Bahia is an experienced content writer with extensive research experience in Immunology and Reproductive Biology. Simran received her Bachelors in Life Sciences from Delhi University, followed by a Master's in Immunology from the Amity Institute of Virology and Immunology. Combining her love for science and writing, Simran enjoys putting a spin on standard methods of medical writing.
Dr. Suneet Singh

Verified By Dr. Suneet Singh

Dr. Suneet is a doctor-turned-Hospital Administrator with a rich 12 years plus multi-faceted experience in the field of operations management, Corporate and Public Health Administration. Formerly a practicing doctor, Dr. Suneet holds a post-graduate degree in Hospital and Healthcare management from one of the country's esteemed Tata Institute of Social Sciences (TISS)

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Best Bone Marrow Transplant Hospitals in India

India hosts over 200 top-notch bone marrow transplant hospitals across the major cities such as New Delhi, Ahmedabad, Chennai, Bangalore, Gurgaon, Mumbai, Hyderabad, Nagpur, and Kochi. These hospitals have the best trained and experienced surgeons and nurses who are dedicated to providing personalized care and specialized services to bone marrow transplant patients.

The donor is required to stay a night at the hospitals to complete the bone marrow transplant procedure. Once the stems are collected, they are sent to the laboratory for harvesting. Then, blood transfusion is performed on the body of the recipient with the help of an injection.

Remember, every cancer hospital and super-specialty unit evaluates the health condition of the patient and whether he or she is capable of tolerating certain medications before the transplant procedure and after it. If everything is fine, the patient is given a go-ahead to undergo the transplant procedure.

Fortis Memorial Research Institute
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Fortis Memorial Research Institute

Gurgaon, India

Medanta The Medicity
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Medanta The Medicity

Gurgaon, India

Artemis Hospital
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Artemis Hospital

Gurgaon, India

Indraprastha Apollo Hospitals
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Indraprastha Apollo Hospitals

New Delhi, India

Max Super Specialty Hospital Saket
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Max Super Specialty Hospital Saket

New Delhi, India

Need help in deciding a best hospital?

Best Liver Transplant Surgeons in India 

The country boasts of stringent infection control regulations, experienced surgeons, multi-facilitated hospitals and advanced treatment facilities.

List of some famous bone marrow transplant doctors in India:

Dr. Rahul Bhargava
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Dr. Rahul Bhargava

New Delhi, India

Dr. Satya Prakash Yadav
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Dr. Satya Prakash Yadav

Gurgaon, India

Dr. Gaurav Kharya
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Dr. Gaurav Kharya

Gurgaon, India

Dr. Vikas Dua
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Dr. Vikas Dua

Gurgaon, India

Dr. Rahul Naithani
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Dr. Rahul Naithani

New Delhi, India

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